| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378662 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A novel series of quinolones was discovered as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a structure-based approach. The lead quinolones exhibited single digit nanomolar potency in the HIV-1 replication assays. The preliminary SAR of these quinolones was also established via systematic structural modifications. These novel and potent quinolones could serve as advanced leads for further optimization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David Ellis, Kelli L. Kuhen, Beth Anaclerio, Baogen Wu, Karen Wolff, Hong Yin, Badry Bursulaya, Jeremy Caldwell, Donald Karanewsky, Yun He,