| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378664 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
This communication details the synthesis, biological activity, and proposed binding mode of a novel class of tri-cyclic derivatives of 1,2-dihydro-pyrimido[4,5-c]pyridazines 1 and 2. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Mark Sabat, John C. VanRens, Todd A. Brugel, Jennifer Maier, Matthew J. Laufersweiler, Adam Golebiowski, Biswanath De, Vijayasurian Easwaran, Lily C. Hsieh, Jeff Rosegen, Steve Berberich, Eric Suchanek, Michael J. Janusz,