| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378669 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Structure–affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at α7 nACh receptors were investigated due to its close structural similarity to a known α7 antagonist.
Graphical abstractAn examination of several aryloxyalkylamine analogs 4 and 5 was undertaken to determine the role of various structural features for binding at homomeric α7 nicotinic acetylcholine receptors. In general, the ring N atom might contribute to affinity but is not essential. In contrast, the N,N,N-trimethyl quaternary amine is a major contributor to α7 binding.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hanan M. Ragab, Jin Sung Kim, Małgorzata Dukat, Hernán Navarro, Richard A. Glennon,