Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378674 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1 inhibitors. The molecules display excellent selectivities (when compared to their triazaspiropiperidine analogues) against the μ opioid receptor as well as the nociceptin/orphanin FQ peptide (NOP) receptor.
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Authors
Daniela Alberati, Simona M. Ceccarelli, Synèse Jolidon, Eva A. Krafft, Anke Kurt, Axel Maier, Emmanuel Pinard, Henri Stalder, Deborah Studer, Andrew W. Thomas, Daniel Zimmerli,