Article ID Journal Published Year Pages File Type
1378674 Bioorganic & Medicinal Chemistry Letters 2006 6 Pages PDF
Abstract
A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1 inhibitors. The molecules display excellent selectivities (when compared to their triazaspiropiperidine analogues) against the μ opioid receptor as well as the nociceptin/orphanin FQ peptide (NOP) receptor.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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