| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378687 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.
Graphical abstractA structurally novel series of selective PPARδ agonists is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert Epple, Ross Russo, Mihai Azimioara, Christopher Cow, Yongping Xie, Xing Wang, John Wityak, Don Karanewsky, Andrea Gerken, Maya Iskandar, Enrique Saez, H. Martin Seidel, Shin-Shay Tian,