| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378691 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The indenoisoquinolines are a novel class of non-camptothecin topoisomerase I (Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top1 during cellular processes. As an ongoing evaluation of the indenoisoquinolines for Top1 inhibition and anticancer activity, indenoisoquinoline analogs have been screened in the National Cancer Institute’s hollow fiber assay (HFA). Some of the derivatives demonstrated significant activity at intraperitoneal and subcutaneous fiber placement sites, along with net cancer cell kill in one or more cell lines.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Morrell, Muthusamy Jayaraman, Muthukaman Nagarajan, Brian M. Fox, Marintha Rae Meckley, Alexandra Ioanoviciu, Yves Pommier, Smitha Antony, Melinda Hollingshead, Mark Cushman,