Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378693 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of compounds bearing tetrahydronaphthalene, benzophenone, propiophenone, and related rigid molecular skeletons functionalized with thiosemicarbazone or unsaturated carbonyl moieties were prepared by chemical synthesis and evaluated for their ability to inhibit the enzyme cruzain. As potential treatment agents for Chagas’ disease, three compounds from the group demonstrate potent inhibition of cruzain with IC50 values of 17, 24, and 80 nM, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rogelio Siles, Shen-En Chen, Ming Zhou, Kevin G. Pinney, Mary Lynn Trawick,