| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378719 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
We have examined the stability of fluorescently-labelled oligonucleotides that are based on the human telomeric repeat [(GGGTTA)3GGG], in which one of the guanines in turn is substituted with inosine. We show that the relative stability of the substitutions is different in the presence of sodium and potassium. The data for potassium suggest a parallel arrangement of the strands, while the sodium form is mixed parallel and antiparallel.
Graphical abstractThe relative stability of intramolecular quadruplexes containing inosine substitutions is different in sodium and potassium.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Antonina Risitano, Keith R. Fox,