Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378722 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A novel pyridine diamine-based cyclic enediyne 1 was synthesized by bis-N-alkylation of 2,6-bis-sulfonamido pyridine 6 followed by deprotection with thiophenol. A variety of salts 1a–c of the parent amine 1 were prepared. Thermal reactivity studies indicated a dependence of the reactivity upon the extent of salt formation. This observation may be useful in pH-based design of enediynes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amit Basak, Moumita Kar, Subrata Mandal,