| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378731 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency and physical properties is discussed, and compound 22 highlighted as having a suitable balance. In vivo pharmacokinetic and acute efficacy studies on this compound are also presented.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Darren McKerrecher, Joanne V. Allen, Suzanne S. Bowker, Scott Boyd, Peter W.R. Caulkett, Gordon S. Currie, Christopher D. Davies, Mark L. Fenwick, Harold Gaskin, Emma Grange, Rod B. Hargreaves, Barry R. Hayter, Roger James, Keith M. Johnson,