| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378739 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The sulfur analogue of sphingomyelin was designed and stereoselectively synthesized from S-benzyl-N-Boc-cysteine. The introduction of the phosphoryl choline moiety was successfully achieved by our own method using 2-bromoethyl dimethyl phosphite and carbon tetrabromide followed by a trimethylamine treatment. The synthesized compound proved to be a useful substrate for monitoring the enzyme activity of sphingomyelinase by detecting the liberated thiol group with a thiol-sensitive reagent.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Toshikazu Hakogi, Shinobu Fujii, Michio Morita, Kiyoshi Ikeda, Shigeo Katsumura,