| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378743 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.
Graphical abstractCompound 15 displayed the profile of a dissociated glucocorticoid in vitro and reduced inflammation in a mouse.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christopher F. Thompson, Nazia Quraishi, Amjad Ali, James R. Tata, Milton L. Hammond, James M. Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, Theresa M. Kelly, Paul Mazur, Shilpa Pandit, Joseph Santoro, Ayesha Sitlani, Chuanlin Wang,