| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378745 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the ϕX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.
Graphical abstractThe title compound has been shown to cleave the ϕX 174 supercoiled plasmid upon photochemical irradiation. It also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eric T. Mack, Dagne Birzniece, Darren R. Veach, William Coyle, R. Marshall Wilson,