| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378759 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.
Graphical abstractA compound library for structure optimization was synthesized to find out highly potent agents. The selected derivatives exhibited excellent in vivo inhibitory effect on tumor growth.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Masao Yoshida, Ichiro Hayakawa, Noriyuki Hayashi, Toshinori Agatsuma, Youko Oda, Fumie Tanzawa, Shiho Iwasaki, Kumiko Koyama, Hidehiko Furukawa, Shinichi Kurakata, Yuichi Sugano,