| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378763 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroo Koyama, Julia K. Boueres, Daniel J. Miller, Joel P. Berger, Karen L. MacNaul, Pei-ran Wang, Marc C. Ippolito, Samuel D. Wright, Arun K. Agrawal, David E. Moller, Soumya P. Sahoo,