Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378770 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
A series of 6-arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity. Further mechanistic study revealed that the inhibitory effect of one representative quinoxaline-5,8-dione on SMC proliferation was mediated by modulation of the extracellular signal-regulated kinase 1/2 signaling pathway in the RAoSMCs.
Graphical abstract6-Arylamino-2,3-bis(pyridin-2-yl)-7-chloro-quinoxaline-5,8-diones were synthesized and evaluated for their antiproliferative activity on rat aortic smooth muscle cells. The quinoxaline-5,8-diones exhibited a potent antiproliferative activity.Figure optionsDownload full-size imageDownload as PowerPoint slide