| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378775 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
Graphical abstractA novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1 (MSK-1), and exemplified by the potent inhibitor 9.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors](/preview/png/1378775.png "First Page Preview: (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors")
Authors
Mark J. Bamford, Michael J. Alberti, Nicholas Bailey, Susannah Davies, David K. Dean, Alessandra Gaiba, Stephen Garland, John D. Harling, David K. Jung, Terence A. Panchal, Christopher A. Parr, Jon G. Steadman, Andrew K. Takle, James T. Townsend,