| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378776 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The novel imidazo[4,5-c]pyridine 1,2,5-oxadiazol-3-yl template affords an excellent start point for identification of inhibitors of a number of protein kinases. Here we report on its optimisation for mitogen and stress-activated protein kinase-1 (MSK-1) inhibitory activity, and selectivity over other kinases.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors](/preview/png/1378776.png "First Page Preview: (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors")
Authors
Mark J. Bamford, Nicholas Bailey, Susannah Davies, David K. Dean, Leann Francis, Terence A. Panchal, Christopher A. Parr, Sanjeet Sehmi, Jon G. Steadman, Andrew K. Takle, James T. Townsend, David M. Wilson,