| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378778 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Eight new camphorato platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against HL-60 human leukemia, 3AO human ovarian carcinoma, BEL-7402 human hepatocarcinoma, and A549 human lung carcinoma cell lines. Most complexes showed good cytotoxic activity against the above-selected cell lines. Among the complexes, two compounds were assayed for their in vivo antitumor activity against LS-174T human colon carcinoma cells implanted in mice. One complex exhibited not only higher in vivo antitumor activity, but also less toxicity than oxaliplatin when it was administered intravenously at a dose of 6 mg/kg three times.
Graphical abstractEight new camphorato platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against four human tumor cell lines. The antitumor activities of compounds 3a and b were assayed in vivo against LS-174T human colon carcinoma cell line. Complex 3b exhibited not only higher in vivo antitumor activity, but also less toxicity than oxaliplatin when it was administered intravenously three times at a dose of 6 mg/kg.Figure optionsDownload full-size imageDownload as PowerPoint slide
