Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378788 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure–activity relationships of these compounds were also studied. The results suggest that compounds 9–22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells.
Graphical abstractThe synthesis, and antibacterial and antiviral activities of 5–24 are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vishnu K. Tandon, Dharmendra B. Yadav, Ravindra V. Singh, Meenu Vaish, Ashok K. Chaturvedi, Praveen K. Shukla,