Quinol fatty alcohols as promoters of axonal growth

The synthesis of three series of quinol fatty alcohols (QFAs) and their biological activities on the promotion of axonal growth are described. Interestingly, the 15-(2,5-dimethoxyphenyl)pentadecan-1-ol, the QFA bearing 15 carbon atoms on the side chain (n = 15), shows the most potent promotion of axonal growth in the presence of both permissive and non-permissive naturally occurring substrates such as Sema3A and myelin proteins.

Graphical abstractThree series of quinol fatty alcohols were synthesized and their capacity to promote axonal growth was evaluated. Q2FA15, bearing 15 carbon atoms on the side chain, exhibits the highest promoting effect (10−9 M) allowing axonal growth on both permissive and non-permissive (glial scar) environments.Figure optionsDownload full-size imageDownload as PowerPoint slide