| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378863 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
We describe the generation of novel EP1 receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.
Graphical abstractThe synthesis and biological activity of a series of novel EP1 receptor antagonists are described. In vitro and in vivo DMPK data are presented for selected compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adrian Hall, Rino A. Bit, Susan H. Brown, Helene M. Chaignot, Iain P. Chessell, Tanya Coleman, Gerard M.P. Giblin, David N. Hurst, Ian R. Kilford, Xiao Q. Lewell, Anton D. Michel, Shiyam Mohamed, Alan Naylor, Riccardo Novelli, Lee Skinner,