| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378865 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The human immunodeficiency virus (HIV) which encodes, among other indispensable enzymes, an aspartic protease that is essential for viral maturation and replication. Numerous inhibitors of the protease have been developed. However, the eventual resistance of HIV-1 to these drugs implies a continuous battle to develop new inhibitors. Proposed herein is a robust, fast, and reliable method employing 19F NMR for the evaluation of the inhibitory activity of new compounds against HIV-1 protease.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Silvia Frutos, Teresa Tarrago, Ernest Giralt,