Studies on the novel α-glucosidase inhibitory activity and structure–activity relationships for andrographolide analogues

A series of analogues of andrographolide were synthesized and evaluated as novel α-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against α-glucosidase whose IC50 value was 16 μM. The structure–activity relationships were also discussed.

Graphical abstractA series of novel α-glucosidase inhibitors were reported and the structure–activity relationships were analyzed.Figure optionsDownload full-size imageDownload as PowerPoint slide