| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378874 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague–Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Atul Kumar, S.R. Pathak, Pervez Ahmad, S. Ray, P. Tewari, A.K. Srivastava,