| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378877 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20 μg/mL concentrations, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fateh V. Singh, Rit Vatsyayan, Uma Roy, Atul Goel,