| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378886 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Two novel tiazofurin analogues 2 and 3 were synthesized starting from d-glucose. The key step of the synthesis was the efficient one-step hydrogen sulfide-mediated conversion of 2-azido-3-O-acyl-ribofuranosyl cyanides to the corresponding 2-amido thiocarboxamides. Compounds 2 and 3 were evaluated for their in vitro antiproliferative activity against certain human tumour cell lines. Remarkably, compound 2 was found to be 570-fold more potent than tiazofurin against MCF-7 cells, while compound 3 showed the most powerful cytotoxicity against HT-29 cancer cells, being almost 100-fold more active than tiazofurin.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mirjana Popsavin, Ljilja Torović, Miloš Svirčev, Vesna Kojić, Gordana Bogdanović, Velimir Popsavin,