| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378891 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.
Graphical abstractReplacement of central phenol in 1 with hydroxy pyrazole resulted in compound 2 which selectively inhibits factor IXa. It is also selective against trypsin-like serine proteases in the coagulation cascade.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dange Vijaykumar, Paul A. Sprengeler, Michael Shaghafi, Jeffrey R. Spencer, Brad A. Katz, Christine Yu, Roopa Rai, Wendy B. Young, Brian Schultz, James Janc,