| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378892 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [125I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.
Graphical abstractA series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [125I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent, orally bioavailable antagonists.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xuemei Wang, Feng Xu, Qingge Xu, Hossen Mahmud, Jonathan Houze, Liusheng Zhu, Michelle Akerman, George Tonn, Liang Tang, Brian E. McMaster, Daniel J. Dairaghi, Thomas J. Schall, Tassie L. Collins, Julio C. Medina,