| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378896 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.
Graphical abstractThe dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase among the diaryl pyrroles evaluated as anticoccidial agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaoxia Qian, Gui-Bai Liang, Dennis Feng, Michael Fisher, Tami Crumley, Sandra Rattray, Paula M. Dulski, Anne Gurnett, Penny Sue Leavitt, Paul A. Liberator, Andrew S. Misura, Samantha Samaras, Tamas Tamas, Dennis M. Schmatz, Matthew Wyvratt,