Article ID Journal Published Year Pages File Type
1378904 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

A series of metabolically robust N-benzyl-indole selective PPARγ modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARγMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARγ full agonists.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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