Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378904 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of metabolically robust N-benzyl-indole selective PPARγ modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocytes. In vivo, these SPPARγMs result in potent glucose lowering in db/db mice and attenuate increases in heart weight and brown adipose tissue that is typically observed in rats upon treatment with PPARγ full agonists.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kun Liu, Regina M. Black, John J. Acton III, Ralph Mosley, Sheryl Debenham, Ramon Abola, Meng Yang, Richard Tschirret-Guth, Lawrence Colwell, Cherrie Liu, Margaret Wu, Chuanlin F. Wang, Karen L. MacNaul, Margaret E. McCann, David E. Moller,