Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378908 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benjamin K. Ayida, Klaus B. Simonsen, Dionisios Vourloumis, Thomas Hermann,