Article ID Journal Published Year Pages File Type
1378908 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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