| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378912 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.
Graphical abstractA general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carlo Ballatore, Simon E. Aspland, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun, Angelo J. Castellino, Amos B. Smith III,