| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378920 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki = 0.45 nM).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhiqiang Guo, Yongsheng Chen, Charles Q. Huang, Timothy D. Gross, Joseph Pontillo, Martin W. Rowbottom, John Saunders, Scott Struthers, Fabio C. Tucci, Qiu Xie, Warren Wade, Yun-Fei Zhu, Dongpei Wu, Chen Chen,