| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378926 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
8-Position variants of cyclazocine have been made where the phenolic 8-OH was replaced by thioamide, amidine, guanidine, urea and thiourea groups. High affinity for opioid receptors was observed for the 8-CSNH2 and 8-NHCHS analogues indicating that these groups are isosteric with not only the 8-OH but with the previously synthesized 8-CONH2 and 8-NHCHO cyclazocine derivatives.
Graphical abstract8-Thiocarboxamido and 8-thioformamido analogues of cyclazocine show high binding affinity for opioid receptors.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Mark P. Wentland, Xufeng Sun, Yigong Bu, Rongliang Lou, Dana J. Cohen, Jean M. Bidlack,