| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378930 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A novel gemcitabine–lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar®.
Graphical abstractThe synthesis and biological evaluation of novel gemcitabine–lipid conjugate is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shoukath M. Ali, Abdul R. Khan, Moghis U. Ahmad, Paul Chen, Saifuddin Sheikh, Imran Ahmad,