Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378931 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.
Graphical abstractThe synthesis of thiosemicarbazone 2 and 4-thiazolidinone derivatives 3 and their evaluation against Toxoplasma gondii are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rômulo P. Tenório, Cristiane S. Carvalho, Carla S. Pessanha, José G. de Lima, Antônio R. de Faria, Antônio J. Alves, Edésio J.T. de Melo, Alexandre J.S. Góes,