| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378937 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
We have developed a practical synthetic route to construct C-aromatic taxane derivatives as three-dimension templates by way of intramolecular alkylation. The usefulness of synthesized compounds as the core template was evaluated by using a newly developed screening system for P-glycoprotein.
Graphical abstractThe synthesis of the C-aromatic taxoid analogues 1–3, and their affinity for P-glycoprotein are reported. An evolution of multidrug resistant reversal activity of 2b is also described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takashi Takahashi, Kazuoki Nakai, Takayuki Doi, Masa Yasunaga, Hiroshi Nakagawa, Toshihisa Ishikawa,