| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378951 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The present study reports the identification and hits to leads optimization of chemokine receptor CCR4 antagonists. Compound 12 is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.
Graphical abstractThe present study reports the identification and hits to leads optimization of CCR4 antagonists. The compound shown is a high affinity, non-cytotoxic antagonist of CCR4 that blocks the functional activity mediated by the receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Ashok V. Purandare, Aiming Gao, Honghe Wan, John Somerville, Christine Burke, Carrie Seachord, Wayne Vaccaro, John Wityak, Michael A. Poss,