| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378953 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
We describe the synthesis and structure/activity relationship of RGD mimetics that are potent inhibitors of the integrin αvβ3. Indol-1-yl propionic acids containing a variety of basic moieties at the 5-position, as well as substitutions alpha and beta to the carboxy terminus were synthesized and evaluated. Novel compounds with improved potency have been identified.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kristi Leonard, Wenxi Pan, Beth Anaclerio, Joan M. Gushue, Zihong Guo, Renee L. DesJarlais, Marge A. Chaikin, Jennifer Lattanze, Carl Crysler, Carl L. Manthey, Bruce E. Tomczuk, Juan Jose Marugan,