| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379048 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Imidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.
Graphical abstractImidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABAA receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Andrew S.R. Jennings, Richard T. Lewis, Michael G.N. Russell, David J. Hallett, Leslie J. Street, José L. Castro, John R. Atack, Susan M. Cook, Rachael Lincoln, Joanna Stanley, Alison J. Smith, David S. Reynolds, Bindi Sohal, Andrew Pike,