Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379050 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.
Graphical abstractA systematic study of anilines led to the discovery of a metabolically robust fluoroindoline replacement for the alkoxy aniline toxicophore in 1. Investigations of the P1 pocket resulted in the discovery of a wide tolerance of functionality leading to the discovery of 11 as a potent and selective inhibitor of cathepsin S.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Phillip B. Alper, Hong Liu, Arnab K. Chatterjee, KhanhLinh T. Nguyen, David C. Tully, Christine Tumanut, Jun Li, Jennifer L. Harris, Tove Tuntland, Jonathan Chang, Perry Gordon, Thomas Hollenbeck, Donald S. Karanewsky,