| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379051 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Several pronucleotide analogs of the model anti-HBV dinucleotide 3′-dA-U2′OMe3′-dA-U2′OMe have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation.
Graphical abstractSynthesis and evaluation of a number of dinucleotide prodrugs are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seetharamaiyer Padmanabhan, John E. Coughlin, Guangrong Zhang, Cassandra J. Kirk, Radhakrishnan P. Iyer,