Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379054 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
We have designed and synthesized a novel series of 3-biphenylamino acid amides as cathepsin K inhibitors based on compound I. In these inhibitors, we have discovered 4-aminophenoxyacetic acids 43 and 47 with good IC50 values, although lipophilic groups are favorable for the hydrophobic S1′ pocket.
Graphical abstractThe synthesis and SAR of 4-aminophenoxyacetic acids as cathepsin K inhibitors are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tsuyoshi Shinozuka, Kousei Shimada, Satoshi Matsui, Takahiro Yamane, Mayumi Ama, Takeshi Fukuda, Motohiko Taki, Satoru Naito,