| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379055 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A new approach to 4″-substituted derivatives of erythromycin and clarithromycin was developed by converting them into corresponding 4″-malonic monoesters. Subsequent carbodiimide coupling with alcohols and amines provided new macrolide derivatives that are capable of binding to 50S ribosomal subunits and inhibiting protein synthesis in cell-free system.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel Sherman, Liqun Xiong, Alexander S. Mankin, Artem Melman,