| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379057 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Schiff base conjugates of p-aminosalicylic acid have been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and cyclic voltammetry. Compounds containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher Clog P values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.
Graphical abstractSchiff base conjugates of p-aminosalicylic acid containing hydroxyl-rich side chains show enhanced antimycobacterial activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. Higher Clog P values and superior radical scavenging activities are thought to be the contributing factors for their enhanced antimycobacterial activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
