| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379061 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.
Graphical abstractA novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian E. Fink, Ashvinikumar V. Gavai, John S. Tokarski, Bindu Goyal, Raj Misra, Hai-Yun Xiao, S. David Kimball, Wen-Ching Han, Derek Norris, Thomas E. Spires, Dan You, Marco M. Gottardis, Matthew V. Lorenzi, Gregory D. Vite,