| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379063 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The design, synthesis, and SAR studies of a structurally novel series of highly potent thrombin receptor (PAR-1) antagonists are described. Compound 30 is a highly potent thrombin receptor antagonist (IC50 = 6.3 nM), a related compound 36 showing efficacy in a monkey ex vivo study.
Graphical abstractThe synthesis and SAR studies of a structurally novel series of highly potent thrombin receptor (PAR-1) antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William J. Greenlee, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Carolyn Foster, Matthew Bryant, Janice Lau,