| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1379064 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
We report the discovery of a novel class of glucocorticoid receptor (GR) ligands based on 1,2-dihydroquinoline molecular scaffold. The compounds exhibit good GR binding affinity and selectivity profile against other nuclear hormone receptors.
Graphical abstractThe SAR study of novel class of glucocorticoid receptor ligands is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hidenori Takahashi, Younes Bekkali, Alison J. Capolino, Thomas Gilmore, Susan E. Goldrick, Richard M. Nelson, Donna Terenzio, Ji Wang, Ljiljana Zuvela-Jelaska, John Proudfoot, Gerald Nabozny, David Thomson,