Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1379067 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic–oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.
Graphical abstractNovel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles with 2-nitroimidazole were designed, synthesized, and evaluated in V79 379 A Chinese hamster cells in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Yan Liu, Yufang Xu, Xuhong Qian, Yi Xiao, Jianwen Liu, Liyun Shen, Junhui Li, Yuanxing Zhang,